Advancing Contaminant Analysis: Leveraging timsTOF Mass Spec to Meet the Current and Future Requirements of POP’s

Per- and polyfluoroalkyl substances (PFAS) are a class of organic compounds that have attracted global attention for their persistence in the environment, exposure to biological organisms, and their adverse health effects. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) is a chromatography-free MS method that performs laser-based ionization and in situ analysis on samples. In this talk, I will present our lab's recent progress in developing MALDI-MS analysis of PFAS with trapped ion mobility (TIMS) on various PFAS and demonstrating its application in fast assessment of PFAS-bacteria interactions.

Talk #2: The versatility of GC-APCI-tims-TOF for sub-ppt measurement of targeted POPs to non-targeted analysis of chemicals of emerging concern   

For the past decades, GC-HRMS based on magnetic sector instruments has been the main technique for dioxin quantification in food and environmental samples. Presented here is a novel workflow which combines GC-APCI with trapped ion mobility (TIMS) as an orthogonal criterion for the dioxin quantitation, and a high-resolution, ultra-sensitive QTOF. One main benefit is the reliable and sensitive quantification of various classes of POP like PCDDs/PCDFs, dioxin-like PCBs or dioxins jointly in a single GC run.